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Activated CHK2 and CHK1 phosphorylate many downstream effectors to amplify and relay the alerts to induce DNA destruction responses (DDRs) these types of as cell cycle arrest, senescence, or apoptosis (25,fifty nine,sixty). ATR-CHK1 is at the heart of your DDR, specifically in the RSR (23,sixty four). ATR orchestrates multiple branches of RSR by si

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